- Excess fat accumulation occurs in adipose tissue, the liver, pancreas and muscles.
- In non-adipose tissues, excess energy leads to lipotoxicity, leading to abnormal glucose and insulin metabolism.
- Muscle lipotoxicity inhibits glucose uptake, leading to peripheral insulin resistance
- Pancreatic lipotoxicity inhibits insulin production.
- Rapid weight loss rapidly restores pancreatic function and reduces insulin resistance.
- VLEDs are a clinically proven method of achieving rapid and sustainable weight loss.
- They should provide the right amount of available carbohydrate to create a state of ketosis.
- A range of VLEDs are available in Australia, but few meet all nutritional requirements.
- Many will need to be reformulated to meet the requirements of Standard 2.9.5