Pharmacokinetic Properties - SummaryÂ
Absorption:
Metformin modified release is not altered by the composition of a meal.
Distribution:
Plasma protein binding of metformin is negligible.
Excretion:
Renal clearance of metformin is > 400 mL/min, indicating that metformin is eliminated by glomerular filtration and tubular secretion. Dosage adjustment should occur therefore in those with renal dysfunction and ceased in renal failure.
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